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Cincinnati Sun
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Critical enzyme in healthy heart function identified
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Washington, Feb 20 : Scientists at Cincinnati Children's Hospital Medical Center and the Howard Hughes Medical Institute have shown that the enzyme calcineurin is critical in controlling normal development and function of heart cells, and that loss of the protein leads to heart problems and death in genetically modified mice.
The study will be published in Feb. 26 in the Journal of Biological Chemistry.
The study demonstrates that calcineurin in hearts of mice is directly linked to proper cardiac muscle contraction, rhythm and maintenance of heart activity. The near total absence of calcineurin in mice leads to heart arrhythmia, failure and death, according to the research team.
Scientists knew previously that calcineurin is important to heart function, but the extent of its role had not been defined prior to the current study. Although the research involved mice, it offers important insights for future studies that could lead to new approaches in diagnosis and treatment of heart patients, said Marjorie Maillet, Ph.D., the study's first author.
"We found that when you eliminate calcineurin, a pool of genes that regulates calcium in the heart went awry. This leads to defects in the growth and proliferation of heart cells, heart disease, arrhythmia, loss of contractility and heart failure and disease," said Dr. Maillet.
Calcium is also important to cardiac growth and the contraction of heart muscle.
Previous studies have linked abnormalities in calcium handling to cardiac disease, especially in adults. In mice genetically bred for calcineurin deficiency, the researchers saw that this deficiency causes a dramatic reduction in the expression of genes that coordinately regulate calcium-handling and contraction.
The scientists also report a newly identified "feed-forward" mechanism, in which the direct activation of calcineurin by calcium augments the expression of genes that regulate calcium-handling proteins in the heart.
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Cincinnati Sun
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The Cincinnati Sun is essentially a local Cincinnati newspaper, but with a national and international perspective, designed to provide readers with a one-stop shop for Cincinnati, national US, regional, and world news coverage, weather and sports information, with live updates on breaking business stories, and what's happening in the financial markets.
The biggest advantage we have is that we are an online newspaper, which means we are constantly refreshing our stories as more and more information comes to hand. Often when a story breaks the initial details are sketchy.
We and our sources around the world work hard to gather more information, verify facts, and provide a perspective of the major stories. Expert opinion often accompanies our articles to better inform readers, and provide a more complete understanding
of the news we deliver.
Financial markets and business reports are regular features as we pin down what's happening, and constantly refresh stock market indice readings, dollar currency rates, and breaking business news reports. Our world sports coverage is a priority, as is our regional news.
We like to think if you're looking for breaking news out of Cincinnati, Ohio, the United States, or the world, you'll look for it first at the Cincinnati Sun. |
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| JW Marriott Ihilani Hotel Resort & Spa |

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This has to be one of the best hotel resorts in Hawaii. 387 luxurious guest rooms, each with it's own mini bar (stocked with...
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