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| Osama bin Laden |
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Cincinnati Sun
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| Breaking News |
| Tea Party grills party leaders
INDIAN HILL - When the chairmen of Hamilton County's political parties - Republican and Democrat - come before a roomful of conservative Tea Party activists, it is not hard to guess which one would...
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| Power Out In Norwood, Hyde Park, Oakley
Residents and business owners in Norwood, Hyde Park and Oakley are dealing with a power outage this evening. Duke Energy says about 1,400 customers are with out power this evening. The cause of the... |
| Large power outage in Norwood
The outage, which began about 6:15 p.m., is affecting between 1,000 and 2,500 customers as of 6:50 p.m., according to Duke Energy. Rookwood Commons and Joseph-Beth Booksellers are among those without... |
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Genetic mutation linked to premature birth identified
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Washington, Feb 2 : Scientists from Division of Reproductive Sciences, part of the Perinatal Institute at Cincinnati Children's Hospital Medical Centre, have identified a genetic mutation that leads to cellular and molecular changes in the pregnant uterus that trigger premature birth.
This gene helps protect the body from genetic instability.
According to Dr Sudhansu K. Dey, director of Reproductive Sciences at Cincinnati Children's and the study's senior investigator, the findings could help lead to the development of new strategies for treating and preventing prematurity,
"Preterm birth and prematurity are problems that pose huge long-term social and economic liabilities, and there is an urgent need for research with new approaches to combat this public health concern," said Dey.
In the new study, researchers targeted certain signaling pathways that function both in pregnancy and during the formation of cancerous tumors.
Signaling pathways are chains of molecular interactions that promote cellular communication. During pregnancy, the pathways analysed by the researchers are usually tightly regulated. In tumour development, however, they become dysfunctional.
The scientists started with a pathway linked to the tumour suppressor gene known as transformation-related protein 53 (Trp53), which encodes another protein known as p53. Mutations of Trp53 are found in a variety of cancers, but its function in female reproduction and other normal physiological processes is not well understood.
The role of p53, sometimes referred to as "the guardian angel gene," is to help preserve genetic stability and prevent mutation.
The researchers generated mice that had the Trp53 gene conditionally deleted in the uterus, causing a deficiency of uterine p53 and removing its influence from the pregnancy process.
The team observed that when the mice mated with fertile males they had normal ovulation, fertilization and embryo implantation. Deficiency of p53, however, activated other signalling pathways in the uterus (involving the proteins pAkt and p21) that set the stage for premature birth.
The study appears in Journal of Clinical Investigation.
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Cincinnati Sun
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The Cincinnati Sun is essentially a local Cincinnati newspaper, but with a national and international perspective, designed to provide readers with a one-stop shop for Cincinnati, national US, regional, and world news coverage, weather and sports information, with live updates on breaking business stories, and what's happening in the financial markets.
The biggest advantage we have is that we are an online newspaper, which means we are constantly refreshing our stories as more and more information comes to hand. Often when a story breaks the initial details are sketchy.
We and our sources around the world work hard to gather more information, verify facts, and provide a perspective of the major stories. Expert opinion often accompanies our articles to better inform readers, and provide a more complete understanding
of the news we deliver.
Financial markets and business reports are regular features as we pin down what's happening, and constantly refresh stock market indice readings, dollar currency rates, and breaking business news reports. Our world sports coverage is a priority, as is our regional news.
We like to think if you're looking for breaking news out of Cincinnati, Ohio, the United States, or the world, you'll look for it first at the Cincinnati Sun. |
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Hotel Review
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| Hilton Waikoloa Village Resort |

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Only 20 miles from Kono International Airport on the Big Island of Hawaii. Access is easy, just turn left at the airport...
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